Depression can manifest in various physical, emotional, and behavioral signs. Some common signs include:

1. Persistent Sadness or Hopelessness: Feeling down, empty, or overwhelmed for an extended period.

2. Loss of Interest or Pleasure: A lack of interest in activities once enjoyed, including hobbies, socializing, or work.

3. Fatigue or Low Energy: Feeling constantly tired, even after rest or sleep, and lacking the energy to carry out everyday tasks.

4. Changes in Sleep Patterns: Difficulty falling asleep, staying asleep, or sleeping too much.

5. Appetite or Weight Changes: Significant weight gain or loss due to changes in appetite.

6. Difficulty Concentrating: Trouble focusing, making decisions, or remembering things.

7. Feelings of Worthlessness or Guilt: Intense self-criticism, feeling unworthy, or excessive guilt about past actions.

8. Irritability or Agitation: Feeling easily annoyed or restless, even over small issues.

9. Physical Symptoms: Unexplained aches, pains, headaches, or digestive issues.

10. Thoughts of Death or Suicide: Persistent thoughts of wanting to escape or not wanting to live.

If you or someone you know is experiencing several of these symptoms, especially thoughts of self-harm, it’s important to seek professional help immediately.